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KMID : 0624620120450060354
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BMB Reports
2012 Volume.45 No. 6 p.354 ~ p.359
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Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein
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Lee Sun-Hwa
Kim Dae-Won
Eom Seon-Ae
Jun Se-Young
Park Mee-Young
Kim Duk-Soo
Kwon Hyung-Joo
Kwon Hyeok-Yil
Han Kyu-Hyung
Park Jin-Seu
Hwang Hyun-Sook
Eum Won-Sik
Choi Soo-Young
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Abstract
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We examined that the protective effects of ANX1 on 12-O-tetradecanoylphorbol- 13-acetate (TPA)-induced skin inflammation in animal models using a Tat-ANX1 protein. Topical application of the Tat-ANX1 protein markedly inhibited TPAinduced ear edema and expression levels of cyclooxygenase-2 (COX-2) as well as pro-inflammatory cytokines such as interleukin- 1 beta (IL-1 β), IL-6, and tumor necrosis factor-alpha (TNF-α). Also, application of Tat-ANX1 protein significantly inhibited nuclear translocation of nuclear factor-kappa B (NF-κ B) and phosphorylation of p38 and extracellular signalregulated kinase (ERK) mitogen-activated protein kinase (MAPK) in TPA-treated mice ears. The results indicate that Tat-ANX1 protein inhibits the inflammatory response by blocking NF-κ B and MAPK activation in TPA-induced mice ears. Therefore, the Tat-ANX1 protein may be useful as a therapeutic agent against inflammatory skin diseases.
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KEYWORD
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Cytokine, Inflammation, MAPK, Tat-ANX1, TPA
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